June 16, 202007 3346 3472stem.core@uq.edu.au

Editing the human genome

Home / Editing the human genome with CRISPR-Cas9
We have a wealth of experience in editing the genome using one of the many currently available forms of Cas9-derived nucleases, including some of the newer versions with improved fidelity and increased target assignment versatility.
StemCore has an extensive experience in both NHEJ and HDR-driven mutagenesis in human stem cells, including traceless correction of genetic mutations, and is able to assist you with the widest range of the human genome modification needs.

DNA_Repair

 

Correction of ATM mutations in iPS cells from two ataxia-telangiectasia patients restores DNA damage and oxidative stress responses  2020 Human Molecular Genetics DA Ovchinnikov, SL Withey, HC Leeson, UW Lei, A Sundarrajan et al.

The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons 2018. Stem Cell Reports  Ovchinnikov DA, Korn, O, Virshup, I., Wells, CA, Wolvetang EJ  

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